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HIV-1 Subtype B Dominance in the Caribbean

Institute of Human Virology, University of Maryland 2009 n=67 publication 10 minutes Evidence: moderate

Nadai Yuka, Eyzaguirre Lindsay M., Sill Anne, Cleghorn Farley, Nolte Claudine, Charurat Manhattan, Collado-Chastel Santiago, Jack Noreen, Bartholomew Courtenay, Pape Jean W., Figueroa Peter, Blattner William A., Carr Jean K.

Title

HIV-1 Subtype B Dominance in the Caribbean

Hypothesis

What is the genetic diversity of HIV-1 subtypes in the Caribbean?

Conclusion

The study confirms that subtype B is the predominant HIV-1 subtype in the Caribbean, with distinct genetic characteristics compared to other regions.

Tracking the Evolution of HIV/AIDS in China from 1989–2009

National Center for AIDS/STD Control and Prevention, China CDC, Beijing, China 2011 n=326157 publication Evidence: high

Jia Zhongwei, Wang Lu, Chen Ray Y., Li Dongmin, Wang Lan, Qin Qianqian, Ding Zhengwei, Ding Guowei, Zang Chunpeng, Wang Ning

Title

Tracking the Evolution of HIV/AIDS in China from 1989–2009

Hypothesis

To determine policy implications, this analysis tracks the evolution of HIV/AIDS infection across China to understand current trends and potential risk factors.

Conclusion

Rates of HIV/AIDS among permanent urban residents, particularly women and elderly men, have increased significantly in recent years.

Key Factors in Protein Evolution

Humboldt-Universität zu Berlin 2009 n=10340 publication Evidence: moderate

Armin Schmitt, Johannes Schuchhardt, Gudrun A. Brockmann

Title

Key Factors in Protein Evolution

Hypothesis

How do physico-chemical forces and the structure of the genetic code influence amino acid exchanges over time?

Conclusion

Protein evolution is primarily influenced by the genetic code shortly after divergence, while physico-chemical properties become more significant as divergence increases.

Fluorescent Labeling of Antibody Fragments Using Split GFP

Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America 2011 publication 10 minutes Evidence: high

Ferrara Fortunato, Listwan Pawel, Waldo Geoffrey S., Bradbury Andrew R. M.

Title

Fluorescent Labeling of Antibody Fragments Using Split GFP

Hypothesis

Can the split green fluorescent protein (GFP) system be used to efficiently label single chain Fvs (scFvs) without affecting their functionality?

Conclusion

The split GFP system allows for effective fluorescent labeling of scFvs without compromising their expression or functionality.

Testing Competition in Invasive Plant Species

York University 2009 n=200 publication 10 minutes Evidence: moderate

Lortie Christopher J., Munshaw Michael, Zikovitz Andrea, Hierro Jose

Title

Testing Competition in Invasive Plant Species

Hypothesis

Does competition between invasive plant species from different regions show evidence of differentiation in competitive abilities?

Conclusion

The study found that Centaurea solstitialis from California had better germination and survival rates compared to those from Argentina, indicating regional differences in competitive abilities.

Cytokine Gene Polymorphisms in Tuberculosis Patients in Pakistan

The Aga Khan University, Karachi, Pakistan 2009 n=376 publication 10 minutes Evidence: moderate

Ambreen Ansari, Talat Najeeha, Jamil Bushra, Hasan Zahra, Razzaki Tashmeem, Dawood Ghaffar, Hussain Rabia

Title

Cytokine Gene Polymorphisms in Tuberculosis Patients in Pakistan

Hypothesis

The study aims to analyze the frequency of cytokine gene polymorphisms linked to high and low responder phenotypes in tuberculosis patients.

Conclusion

The study found significant associations between specific cytokine genotypes and the severity of tuberculosis.

C/EBPβ Phosphorylation Signaling and Lung Injury in Mice

Department of Medicine, VA Healthcare Center, San Diego, California, United States of America 2011 n=20 publication 10 minutes Evidence: moderate

Martina Buck, Mario Chojkier, Regine Schneider-Stock

Title

C/EBPβ Phosphorylation Signaling and Lung Injury in Mice

Hypothesis

The RSK-C/EBPβ-Thr217 phosphorylation pathway may be critical for lung injury and fibrogenesis.

Conclusion

Blocking the RSK-C/EBPβ phosphorylation pathway reduces lung injury and fibrosis in mice.

Cross-Modal Prediction in Speech Perception

Universitat Pompeu Fabra, Barcelona, Spain 2011 n=34 publication Evidence: moderate

Sánchez-García Carolina, Alsius Agnès, Enns James T., Soto-Faraco Salvador

Title

Cross-Modal Prediction in Speech Perception

Hypothesis

Can prior unimodal contextual information improve audiovisual processing in speech perception?

Conclusion

Visual speech information can enhance the processing of subsequent auditory input through predictive mechanisms.

Developmental Patterns of Auditory Responses in Children

Cincinnati Children's Hospital Medical Center 2009 n=80 publication Evidence: high

Kotecha Rupesh, Pardos Maria, Wang Yingying, Wu Ting, Horn Paul, Brown David, Rose Douglas, deGrauw Ton, Xiang Jing

Title

Developmental Patterns of Auditory Responses in Children

Hypothesis

A comprehensive analysis of M50, M70, and M100 would reveal at least one component that changes significantly with age.

Conclusion

The study found clear developmental patterns in the auditory cortex of children, with M70 being a key indicator of auditory development.

MMP-10 Promotes Invasion of Head and Neck Cancer

Hiroshima University, Japan 2011 n=116 publication 10 minutes Evidence: high

Deraz Elsayed Mohamed, Kudo Yasusei, Yoshida Maki, Obayashi Mariko, Tsunematsu Takaaki, Tani Hirotaka, Siriwardena Samadarani B. S. M., Kiekhaee Mohammad Reza, Qi Guangying, Iizuka Shinji, Ogawa Ikuko, Campisi Giuseppina, Muzio Lorenzo Lo, Abiko Yoshimitsu, Kikuchi Akira, Takata Takashi

Title

MMP-10 Promotes Invasion of Head and Neck Cancer

Hypothesis

MMP-10 plays a significant role in the invasion and metastasis of head and neck squamous cell carcinoma (HNSCC).

Conclusion

MMP-10 is important for the invasion and metastasis of HNSCC and may serve as a predictive marker for metastasis.

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