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Recent Publications

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Ngn2 and NeuroD1 in Hippocampal Neurogenesis

Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund, Sweden 2009 publication 10 minutes Evidence: high

Roybon Laurent, Hjalt Tord, Stott Simon, Guillemot Francois, Li Jia-Yi, Brundin Patrik

Title

Ngn2 and NeuroD1 in Hippocampal Neurogenesis

Hypothesis

Ngn2 and NeuroD1 play critical roles in the production and differentiation of granule neurons in the hippocampus.

Conclusion

Ngn2 is essential for the production and amplification of granule neuroblasts, while NeuroD1 directs their differentiation into neurons.

Gene Silencing of the MLL Gene and Its Role in Leukemia

The Netherlands Cancer Institute 2011 publication Evidence: moderate

Gomez-Benito Maria, Loayza-Puch Fabricio, Oude Vrielink Joachim, Odero Maria D., Agami Reuven

Title

Gene Silencing of the MLL Gene and Its Role in Leukemia

Hypothesis

Loss of the MLL 3′UTR could have a role in generating high MLL-PG levels and leukemia development.

Conclusion

MLL translocations relieve oncogenic MLL-PG fusions from the repressive MLL 3′UTR, contributing to higher activity of these genes and leukemia development.

Plasma Glutamate and Glutamine Levels in Children with High-Functioning Autism

Hamamatsu University School of Medicine 2011 n=45 publication Evidence: moderate

Shimmura Chie, Suda Shiro, Tsuchiya Kenji J., Hashimoto Kenji, Ohno Koji, Matsuzaki Hideo, Iwata Keiko, Matsumoto Kaori, Wakuda Tomoyasu, Kameno Yosuke, Suzuki Katsuaki, Tsujii Masatsugu, Nakamura Kazuhiko, Takei Nori, Mori Norio

Title

Plasma Glutamate and Glutamine Levels in Children with High-Functioning Autism

Hypothesis

Plasma levels of glutamate, but not those of other amino acids, would be elevated in children with autism relative to those of healthy children.

Conclusion

The study suggests that plasma glutamate and glutamine levels can serve as a diagnostic tool for the early detection of autism.

Evolution of tRNA Gene Arrays in Entamoeba

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine 2007 n=20000 publication Evidence: moderate

Tawari Blessing, Ali Ibne Karim M., Scott Claire, Quail Michael A., Berriman Matthew, Hall Neil, Clark C. Graham

Title

Evolution of tRNA Gene Arrays in Entamoeba

Hypothesis

What are the origins and evolution of the unique tRNA gene organization in the genus Entamoeba?

Conclusion

The study found that tRNA arrays are a common feature in Entamoeba species, with significant variations in their organization and structure across different species.

Iron Imbalance in Prion Diseases

Case Western Reserve University 2009 n=20 publication 15 minutes Evidence: high

Ajay Singh, Alfred Orina Isaac, Xiu Luo, Mohan Maradumane L., Mark L. Cohen, Fusong Chen, Qingzhong Kong, Jason Bartz, Neena Singh

Title

Iron Imbalance in Prion Diseases

Hypothesis

Is there an imbalance of brain iron homeostasis in prion diseases that contributes to neurotoxicity?

Conclusion

Prion disease-affected brains show a state of iron deficiency despite increased total iron levels, likely due to sequestration in PrPSc-ferritin complexes.

Using Genetic Control to Fight Dengue Fever

University of Oxford 2011 publication Evidence: moderate

Alphey Nina, Alphey Luke, Bonsall Michael B.

Title

Using Genetic Control to Fight Dengue Fever

Hypothesis

Can genetic vector control methods effectively reduce dengue transmission and costs compared to traditional methods?

Conclusion

The study suggests that genetic control strategies could eliminate dengue at a lower cost than the direct and indirect costs of the disease.

Cholesterol Metabolism in Mycobacterium tuberculosis

University of British Columbia 2009 n=20 publication 10 minutes Evidence: high

Yam Katherine C., D'Angelo Igor, Kalscheuer Rainer, Zhu Haizhong, Wang Jian-Xin, Snieckus Victor, Ly Lan H., Converse Paul J., Jacobs William R. Jr., Strynadka Natalie, Eltis Lindsay D.

Title

Cholesterol Metabolism in Mycobacterium tuberculosis

Hypothesis

Does cholesterol metabolism play a role in the pathogenesis of Mycobacterium tuberculosis?

Conclusion

The study shows that cholesterol metabolism is crucial for the survival and virulence of Mycobacterium tuberculosis during infection.

Survival of the Contralateral Cruciate Ligament in Dogs with Unilateral Rupture

University of Wisconsin-Madison, School of Veterinary Medicine 2011 n=380 publication 10 minutes Evidence: moderate

Peter Muir, Zeev Schwartz, Sarah Malek, Abigail Kreines, Sady Y. Cabrera, Nicole J. Buote, Jason A. Bleedorn, Susan L. Schaefer, Gerianne Holzman, Zhengling Hao

Title

Survival of the Contralateral Cruciate Ligament in Dogs with Unilateral Rupture

Hypothesis

Some dogs with unilateral cranial cruciate ligament rupture may be protected from the risk of subsequent contralateral rupture.

Conclusion

Subsequent contralateral CrCLR is common in client-owned dogs, with a median ligament survival time of 947 days.

The Role of Epstein-Barr Virus Protein BHRF1 in Burkitt Lymphoma

Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, United Kingdom 2009 publication Evidence: high

Kelly Gemma L., Long Heather M., Stylianou Julianna, Thomas Wendy A., Leese Alison, Bell Andrew I., Bornkamm Georg W., Mautner Josef, Rickinson Alan B., Rowe Martin

Title

The Role of Epstein-Barr Virus Protein BHRF1 in Burkitt Lymphoma

Hypothesis

Does the Epstein-Barr virus protein BHRF1 contribute to the resistance to apoptosis in Burkitt lymphoma cells?

Conclusion

The study provides evidence that BHRF1, a viral bcl2 homologue, is constitutively expressed in Burkitt lymphoma cells and contributes to their resistance to apoptosis.

Dicer1 Depletion in Male Germ Cells Leads to Infertility

University of Geneva Medical School 2011 n=16 publication 10 minutes Evidence: high

Romero Yannick, Meikar Oliver, Papaioannou Marilena D., Conne Béatrice, Grey Corinne, Weier Manuela, Pralong François, De Massy Bernard, Kaessmann Henrik, Vassalli Jean-Dominique, Kotaja Noora, Nef Serge

Title

Dicer1 Depletion in Male Germ Cells Leads to Infertility

Hypothesis

To investigate the extent to which DICER1 is required for germ cell development and spermatogenesis in mice.

Conclusion

DICER1 is essential for the meiotic and haploid phases of spermatogenesis, and its depletion leads to infertility due to multiple defects in sperm development.

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