MMP-10 Promotes Invasion of Head and Neck Cancer
Author Information
Author(s): Deraz Elsayed Mohamed, Kudo Yasusei, Yoshida Maki, Obayashi Mariko, Tsunematsu Takaaki, Tani Hirotaka, Siriwardena Samadarani B. S. M., Kiekhaee Mohammad Reza, Qi Guangying, Iizuka Shinji, Ogawa Ikuko, Campisi Giuseppina, Muzio Lorenzo Lo, Abiko Yoshimitsu, Kikuchi Akira, Takata Takashi
Primary Institution: Hiroshima University, Japan
Hypothesis
MMP-10 plays a significant role in the invasion and metastasis of head and neck squamous cell carcinoma (HNSCC).
Conclusion
MMP-10 is important for the invasion and metastasis of HNSCC and may serve as a predictive marker for metastasis.
Supporting Evidence
- High expression of MMP-10 was observed in 76.7% of HNSCC cases.
- MMP-10 expression correlated significantly with invasion patterns and metastasis.
- Knockdown of MMP-10 suppressed the invasion of HNSCC cells.
- MMP-10 overexpression enhanced the invasive activity of HNSCC cells.
- Patients with high MMP-10 expression tended to have poor prognosis.
Takeaway
MMP-10 helps cancer cells move and spread in head and neck cancer, which can make the disease worse.
Methodology
The study involved immunohistochemistry to assess MMP-10 expression in HNSCC cases and in vitro assays to evaluate the effects of MMP-10 overexpression and knockdown on cell invasion.
Limitations
The study primarily focused on MMP-10 without exploring other potential factors influencing invasion.
Participant Demographics
116 HNSCC cases, including 32 male and 17 female patients from Italy, and 42 male and 9 female patients from Sri Lanka.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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