PubSort

Pubsort is a free search engine for publications that pre-summarizes each paper’s key findings, hypothesis, conclusion, and supporting evidence.

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Recent Publications

MYCT1-TV: A New Transcript Linked to Laryngeal Cancer

China Medical University 2011 n=40 publication 10 minutes Evidence: moderate

Fu Shuang, Guo Yan, Chen Hong, Xu Zhen-Ming, Qiu Guang-Bin, Zhong Ming, Sun Kai-Lai, Fu Wei-Neng

Title

MYCT1-TV: A New Transcript Linked to Laryngeal Cancer

Hypothesis

MYCT1-TV is regulated by c-Myc and may play a role in laryngeal carcinogenesis.

Conclusion

MYCT1-TV is down-regulated in laryngeal squamous cell carcinoma and may contribute to its development.

Bacterial artificial chromosomes improve protein production in mammalian cells

Ludwig Boltzmann Institute for Cancer Research 2009 n=2000 publication Evidence: high

Blaas Leander, Musteanu Monica, Eferl Robert, Bauer Anton, Casanova Emilio

Title

Bacterial artificial chromosomes improve protein production in mammalian cells

Hypothesis

Can Bacterial Artificial Chromosomes (BACs) enhance recombinant protein production in mammalian cells compared to conventional vectors?

Conclusion

Using Bacterial Artificial Chromosomes for protein production significantly increases yield and stability compared to conventional methods.

Study of Alloxan Inhibitors for Matrix Metalloproteinase-2

University of Bari “Aldo Moro” 2011 publication Evidence: moderate

Giangreco Ilenia, Lattanzi Gianluca, Nicolotti Orazio, Catto Marco, Laghezza Antonio, Leonetti Francesco, Stefanachi Angela, Carotti Angelo

Title

Study of Alloxan Inhibitors for Matrix Metalloproteinase-2

Hypothesis

Can alloxan-based compounds be effectively modified to inhibit MMP-2?

Conclusion

The study found that modified alloxan compounds can effectively inhibit MMP-2 with high affinity and selectivity.

Improving Bacillus licheniformis Laccase Expression

Institute of Technical Biochemistry, Universitaet Stuttgart 2009 n=10000 publication Evidence: high

Koschorreck Katja, Schmid Rolf D, Urlacher Vlada B

Title

Improving Bacillus licheniformis Laccase Expression

Hypothesis

Can random and site-directed mutagenesis improve the functional expression and activity of Bacillus licheniformis laccase?

Conclusion

The double mutant K316N/D500G of Bacillus licheniformis CotA laccase shows significantly improved expression and activity, making it suitable for biotechnological applications.

Identifying Biomarkers for ALS in Blood Samples

Dulbecco Telethon Institute, Milano, Italy 2011 n=94 publication 10 minutes Evidence: high

Nardo Giovanni, Pozzi Silvia, Pignataro Mauro, Lauranzano Eliana, Spano Giorgia, Garbelli Silvia, Mantovani Stefania, Marinou Kalliopi, Papetti Laura, Monteforte Marta, Torri Valter, Paris Luca, Bazzoni Gianfranco, Lunetta Christian, Corbo Massimo, Mora Gabriele, Bendotti Caterina, Bonetto Valentina

Title

Identifying Biomarkers for ALS in Blood Samples

Hypothesis

Can specific protein biomarkers in peripheral blood mononuclear cells (PBMC) help diagnose and monitor amyotrophic lateral sclerosis (ALS)?

Conclusion

The study found that PBMC multiprotein biomarkers can significantly aid in diagnosing ALS and understanding its progression.

Mitochondrial Function and Memory in Mice

Graduate School of Life and Environmental Sciences, University of Tsukuba 2008 n=30 publication 10 minutes Evidence: high

Tanaka Daisuke, Nakada Kazuto, Takao Keizo, Ogasawara Emi, Kasahara Atsuko, Sato Akitsugu, Yonekawa Hiromichi, Miyakawa Tsuyoshi, Hayashi Jun-Ichi

Title

Mitochondrial Function and Memory in Mice

Hypothesis

High loads of pathogenic mitochondrial DNA mutations impair spatial remote memory in mice.

Conclusion

Normal mitochondrial respiratory function is necessary for retention and consolidation of memory trace, and deficiencies in this function due to high loads of mutated mitochondrial DNA lead to impaired spatial remote memory.

Using Plants to Silence Genes in Aphids

The John Innes Centre, Norwich Research Park, Norwich, United Kingdom 2011 n=6 publication 10 minutes Evidence: moderate

Marco Pitino, Alexander D. Coleman, Massimo E. Maffei, Christopher J. Ridout, Saskia A. Hogenhout

Title

Using Plants to Silence Genes in Aphids

Hypothesis

Can plant-mediated RNA interference (RNAi) effectively silence genes in the green peach aphid, Myzus persicae?

Conclusion

The study demonstrates that plant-mediated RNAi can effectively silence genes in aphids, leading to reduced progeny production.

Blind Search for Protein Modifications Using Mass Spectrometry

Department of Informatics, University of Bergen 2008 publication Evidence: moderate

Barsnes Harald, Mikalsen Svein-Ole, Eidhammer Ingvar

Title

Blind Search for Protein Modifications Using Mass Spectrometry

Hypothesis

Can a blind search algorithm effectively identify post-translational modifications and amino acid substitutions in proteins using peptide mass fingerprints?

Conclusion

The developed algorithm can indicate post-translational modifications or amino acid substitutions in proteins without prior assumptions.

Toothache and Factors in Brazilian Adults

Universidade do Planalto Catarinense 2009 n=1805 publication 10 minutes Evidence: moderate

Kuhnen Mirian, Peres Marco A, Masiero Anelise V, Peres Karen G

Title

Toothache and Factors in Brazilian Adults

Hypothesis

What is the prevalence of toothache and its associated factors in adults of Lages, Southern Brazil?

Conclusion

The prevalence of toothache in adults of Lages is a significant dental public health issue.

Comparing Mechanical Properties of Foot Surgery Staples

Robert Jones & Agnes Hunt Orthopaedic Hospital 2009 n=15 publication Evidence: moderate

Rethnam Ulfin, Kuiper Jan, Makwana Nilesh

Title

Comparing Mechanical Properties of Foot Surgery Staples

Hypothesis

There is no difference in stiffness between the staples.

Conclusion

The Richards staple is stiffer but permanently deforms, while Memoclip staples are easier to handle and do not deform permanently.

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