Effects of Boiogito on Obesity in Mice
Author Information
Author(s): Shimada Tsutomu, Akase Tomoko, Kosugi Mitsutaka, Aburada Masaki
Primary Institution: Musashino University
Hypothesis
Does Boiogito have a preventive effect on metabolic disorders in TSOD mice, a model of spontaneous obese type II diabetes mellitus?
Conclusion
Boiogito showed a significant anti-obesity effect in TSOD mice but did not effectively prevent various symptoms of metabolic syndrome.
Supporting Evidence
- Boiogito significantly suppressed body weight gain in TSOD mice.
- Boiogito showed a significant suppressive effect on accumulation of subcutaneous fat.
- Boiogito treatment significantly decreased total cholesterol and triglyceride levels in TSOD mice.
Takeaway
Boiogito can help mice lose weight, but it doesn't fix all the health problems that come with being overweight.
Methodology
The study used TSOD and TSNO mice to assess the effects of Boiogito on body weight, fat accumulation, and metabolic parameters over 8 weeks.
Limitations
Boiogito did not improve insulin resistance or alleviate hypertension and peripheral neuropathy in TSOD mice.
Participant Demographics
Male TSOD and TSNO mice aged 4 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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