Developing a Highly Stable PLGA-mPEG Nanoparticle Loaded with Cisplatin for Chemotherapy of Ovarian Cancer
2011

Developing a Highly Stable Cisplatin Loaded Nanoparticle for Ovarian Cancer Chemotherapy

Sample size: 10 publication 10 minutes Evidence: moderate

Author Information

Author(s): Cheng Lihua, Jin Chengmeng, Lv Wen, Ding Qiuping, Han Xu

Primary Institution: Zhejiang University

Hypothesis

Can a nanoparticle formulation improve the delivery and efficacy of cisplatin for ovarian cancer treatment?

Conclusion

The developed cisplatin-loaded nanoparticle is a promising formulation for effective ovarian cancer therapy with reduced side effects.

Supporting Evidence

  • The nanoparticles showed a high encapsulation efficiency of 72%.
  • The median lethal dose of the nanoparticles was significantly higher than that of free cisplatin.
  • Cisplatin-loaded nanoparticles demonstrated controlled release and reduced toxicity.
  • Histopathological examination showed no significant damage to major organs in treated mice.

Takeaway

Scientists created tiny particles to carry a cancer drug called cisplatin, making it safer and more effective for treating ovarian cancer.

Methodology

Nanoparticles were created using a modified solvent evaporation method, and their effectiveness was tested in vitro and in vivo.

Potential Biases

Potential bias in the selection of animal models and treatment regimens.

Limitations

The study may not fully represent clinical outcomes due to the animal model used.

Participant Demographics

ICR and BALB/c mice were used for testing.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0025433

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