Genetic Effects of IRF5 on Lupus in Koreans
Author Information
Author(s): Shin Hyoung Do, Sung Yoon-Kyoung, Choi Chan-Bum, Lee Soo Ok, Lee Hye Won, Bae Sang-Cheol
Primary Institution: SNP Genetics Inc. and Hanyang University
Hypothesis
Are IRF5 gene polymorphisms associated with systemic lupus erythematosus in a Korean population?
Conclusion
The study found that IRF5 variants are associated with an increased risk of systemic lupus erythematosus in both white and Asian populations.
Supporting Evidence
- The rs2004640 T allele was found at a higher frequency in SLE cases than controls.
- The study replicated previous findings from white populations regarding IRF5 variants and SLE.
- A combined analysis of multiple cohorts showed consistent associations of the rs2004640 T allele with SLE.
Takeaway
This study looked at genes in Korean people to see if they are linked to lupus, and found that certain gene changes are related to a higher chance of getting the disease.
Methodology
593 SLE patients and 972 controls were genotyped using the TaqMan method, and statistical analyses were performed to evaluate genetic associations.
Limitations
The study is limited to a specific ethnic group and may not be generalizable to other populations.
Participant Demographics
593 SLE patients (35 males, 558 females) and 972 healthy controls (139 males, 832 females) from Korea.
Statistical Information
P-Value
0.0003
Confidence Interval
1.14–1.54
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website