Oxygen Levels and Mortality in ICU Patients
Author Information
Author(s): Evert de Jonge, Linda Peelen, Peter J. Keijzers, Hans Joore, Dylan de Lange, Peter HJ van der Voort, Robert J. Bosman, Ruud AL de Waal, Ronald Wesselink, Nicolette F. de Keizer
Primary Institution: Academic Medical Center, Amsterdam, The Netherlands
Hypothesis
Is in-hospital mortality associated with the administered fraction of oxygen in inspired air (FiO2) and achieved arterial partial pressure of oxygen (PaO2)?
Conclusion
High FiO2 and both low and high PaO2 values in the first 24 hours after admission are independently associated with increased in-hospital mortality in ICU patients.
Supporting Evidence
- Higher FiO2 values were associated with increased in-hospital mortality.
- A U-shaped relationship was found between PaO2 values and mortality.
- The study included a large sample size of over 36,000 patients.
Takeaway
Giving too much or too little oxygen to patients in the ICU can be dangerous and may lead to higher chances of dying.
Methodology
Retrospective, observational study analyzing data from 36,307 patients treated with mechanical ventilation in 50 Dutch ICUs.
Potential Biases
Potential confounding factors related to patient severity may not have been fully accounted for.
Limitations
The study is observational, and the association between mortality and oxygenation may not be causal.
Participant Demographics
Patients were admitted to ICUs in the Netherlands, with a mean age of 62.5 years and 60.1% male.
Statistical Information
P-Value
0.05
Confidence Interval
1.12 to 1.34
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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