Quercetin Protects Lymphocytes from Dimethoate Damage
Author Information
Author(s): Gargouri Bochra, Mansour Riadh Ben, Abdallah Fatma Ben, Elfekih Abdelfetteh, Lassoued Saloua, Khaled Hamden
Primary Institution: Institut Supérieur de Biotechnologie de Sfax
Hypothesis
Does quercetin alleviate the cytotoxic effects of Dimethoate in human peripheral blood lymphocytes?
Conclusion
Quercetin can protect against oxidative stress caused by Dimethoate by reducing lipid peroxidation and increasing antioxidant enzyme activities in human lymphocytes.
Supporting Evidence
- Dimethoate increased malondialdehyde levels and decreased thiol levels in lymphocytes.
- Quercetin pretreatment significantly reduced malondialdehyde levels compared to Dimethoate alone.
- Quercetin inhibited protein oxidation in lymphocytes treated with Dimethoate.
- SOD and CAT activities increased significantly with Dimethoate treatment, but were reduced with quercetin pretreatment.
Takeaway
This study shows that quercetin can help protect our blood cells from damage caused by a pesticide called Dimethoate.
Methodology
Lymphocytes were treated with different concentrations of Dimethoate, with and without quercetin pretreatment, and various biochemical assays were performed to assess oxidative stress markers.
Limitations
The study was conducted in vitro, and results may not fully translate to in vivo conditions.
Participant Demographics
10 normal volunteers donated blood for the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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