Lipoprotein Lipase Variant Linked to Lipoprotein Size in Metabolic Syndrome
Author Information
Author(s): Alexis C. Wood, Stephen Glasser, W. Timothy Garvey, Edmond K. Kabagambe, Ingrid B. Borecki, Hemant K. Tiwari, Michael Y. Tsai, Paul N. Hopkins, Jose M. Ordovas, Donna K. Arnett
Primary Institution: University of Alabama at Birmingham
Hypothesis
Is there an association between lipoprotein lipase gene variants and lipoprotein diameter patterns in individuals with metabolic syndrome?
Conclusion
The study found that the S447X variant of lipoprotein lipase is associated with larger VLDL particle sizes in individuals with metabolic syndrome.
Supporting Evidence
- The study identified two groups of individuals with different lipoprotein diameter patterns.
- Group 2 had significantly more carriers of the S447X variant compared to Group 1.
- Both groups met the ATP-III criteria for metabolic syndrome.
Takeaway
This study shows that a specific gene variant can affect the size of fat particles in the blood, which is important for people with metabolic syndrome.
Methodology
Latent class analysis was used to group individuals based on the diameter of their fasting lipoproteins, and mixed linear models were applied to assess associations with gene variants.
Potential Biases
The study did not stratify results by gender due to the small sample size, which could introduce bias.
Limitations
The study had a small sample size and was limited to individuals of European descent, which may affect the generalizability of the findings.
Participant Demographics
The majority of participants were of European descent, with a mix of men and women.
Statistical Information
P-Value
0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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