Cardiotrophin-1: a new player in energy metabolism with potential therapeutic application
2011
Cardiotrophin-1 and Energy Metabolism
publication
Evidence: moderate
Author Information
Author(s): Bustos Matilde, Moreno-Aliaga María J, Prieto Jesús
Primary Institution: University of Navarra
Hypothesis
Cardiotrophin-1 (CT-1) plays a key role in energy metabolism and may have therapeutic applications for obesity and type 2 diabetes.
Conclusion
CT-1 has potential as a treatment for obesity and type 2 diabetes by regulating energy metabolism.
Supporting Evidence
- CT-1 is upregulated by fasting and downregulated by refeeding.
- CT-1 null mice showed reduced energy expenditure and developed obesity and insulin resistance.
- Administration of recombinant CT-1 decreased body weight by reducing food intake and enhancing energy expenditure.
- CT-1 treatment corrected obesity and associated diabetes in animal models.
Takeaway
Cardiotrophin-1 is a substance in our body that helps control how we use energy, and it might help people who are overweight or have diabetes.
Methodology
The study involved analyzing the metabolic effects of CT-1 in animal models and observing its impact on energy expenditure and obesity.
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