Magnesium and Amiodarone for Preventing Arrhythmia After Heart Surgery
Author Information
Author(s): Tiryakioglu Osman, Demirtas Sinan, Ari Hasan, Tiryakioglu Selma Kenar, Huysal Kagan, Selimoglu Ozer, Ozyazicioglu Ahmet
Primary Institution: Bursa Yuksek İhtisas Education and Research Hospital
Hypothesis
Can prophylactic magnesium sulphate and amiodarone effectively prevent postoperative arrhythmias in patients undergoing coronary bypass operations?
Conclusion
Both magnesium sulphate and amiodarone are effective in preventing postoperative arrhythmias, with amiodarone being more effective for total arrhythmia treatment.
Supporting Evidence
- Magnesium levels were significantly higher in the magnesium group compared to the amiodarone group postoperatively.
- Amiodarone was significantly more effective than magnesium sulphate in treating total arrhythmia.
- Ventricular arrhythmia was more common in the magnesium prophylaxis group.
Takeaway
Doctors tested two medicines to help prevent heart rhythm problems after heart surgery. They found that both worked, but one was better at stopping certain types of heart problems.
Methodology
192 patients undergoing coronary artery bypass grafting were divided into three groups: one received magnesium sulphate, another received amiodarone, and the third received a placebo.
Potential Biases
Potential bias in patient selection and exclusion criteria may affect generalizability.
Limitations
The study did not include patients with preoperative renal insufficiency or other significant cardiac pathologies.
Participant Demographics
Patients undergoing coronary artery bypass grafting, with a mean age of approximately 58-61 years.
Statistical Information
P-Value
0.015
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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