Using Antibody Testing to Improve Lymphatic Filariasis Surveillance in the South Pacific
Author Information
Author(s): Joseph Hayley, Maiava Fuatai, Naseri Take, Taleo Fasihah, ‘Ake Malakai, Capuano Corinne, Melrose Wayne
Primary Institution: Lymphatic Filariasis Support Centre, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University
Hypothesis
Does the presence of CFA positive children accurately reflect the cessation of lymphatic filariasis transmission?
Conclusion
CFA testing alone is insufficient for identifying areas of ongoing transmission in Samoa, highlighting the need for antibody serology in surveillance strategies.
Supporting Evidence
- No CFA positive children were detected in Tonga and Vanuatu, indicating interrupted transmission.
- Samoa showed ongoing transmission with detectable Mf and CFA positive children.
- Antibody prevalence was significantly higher in Samoa compared to Tonga and Vanuatu.
Takeaway
This study found that just checking for certain infections in kids isn't enough to know if a disease is gone; we also need to look for antibodies to get a clearer picture.
Methodology
The study involved child transmission surveys and antibody testing in Samoa, Tonga, and Vanuatu, using stratified cluster sampling and filter paper for antibody serology.
Potential Biases
Potential biases may arise from the sampling methods and the reliance on self-reported data for participation.
Limitations
The study's findings may not be generalizable beyond the specific regions studied, and the reliance on antibody testing requires further validation.
Participant Demographics
Participants included children aged 5 to 10 years from Samoa, Tonga, and Vanuatu.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI = 43–75
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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