Understanding Immunity to Filovirus Infections

publication Evidence: moderate

Author Information

Author(s): Bradfute Steven B., Bavari Sina

Primary Institution: United States Army Medical Research Institute of Infectious Diseases

What are the correlates of immunity to filovirus infection?

The study highlights the complexity of immune responses to filovirus infections and the need for further research to understand these mechanisms.

Filoviruses can cause severe, often fatal hemorrhagic fever in humans.
Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections.
It is likely that there are several types of successful immune responses, depending on the type of filovirus.

Filoviruses can make people very sick, and scientists are trying to figure out how our bodies can fight them off better.

This review summarizes existing literature on immune responses to filovirus infections.

There is limited data on immune responses in humans and significant gaps in knowledge about filovirus immunity.

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