Study of Porin Genes in Mycobacterium fortuitum and Their Role in Growth
Author Information
Author(s): Sharbati Soroush, Schramm Kira, Rempel Sonja, Wang Hwa, Andrich Ronny, Tykiel Verena, Kunisch Ralph, Lewin Astrid
Primary Institution: Freie Universität Berlin
Hypothesis
The growth rate of Mycobacterium fortuitum is influenced by the expression of porin genes.
Conclusion
Porin expression significantly affects the growth and antibiotic susceptibility of Mycobacterium fortuitum.
Supporting Evidence
- PorM1 and PorM2 enhance the growth of M. fortuitum strains.
- Repression of porin expression decreases growth rates.
- Porin expression varies among different strains of M. fortuitum.
- Over-expression of porins affects antibiotic diffusion into cells.
Takeaway
This study found that certain genes help Mycobacterium fortuitum grow faster and deal with antibiotics better.
Methodology
Porin genes were cloned and characterized, and their effects on growth rates were analyzed using various strains of Mycobacterium fortuitum.
Limitations
The study primarily focused on a limited number of strains and may not represent all Mycobacterium fortuitum variants.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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