Filoviral Immune Evasion Mechanisms
Author Information
Author(s): Ramanan Parameshwaran, Shabman Reed S., Brown Craig S., Amarasinghe Gaya K., Basler Christopher F., Leung Daisy W.
Primary Institution: Iowa State University
Hypothesis
How do filoviral proteins evade the host immune response?
Conclusion
Filoviral proteins, particularly VP35, VP24, and VP40, employ various mechanisms to suppress the host's innate immune responses, contributing to their virulence.
Supporting Evidence
- Filoviruses cause severe hemorrhagic fever in humans and non-human primates.
- EBOV VP35 inhibits the phosphorylation of IRF-3/7, impairing the immune response.
- MARV VP40 inhibits STAT phosphorylation, blocking immune signaling.
- VP24 prevents nuclear translocation of phospho-STAT1, rendering cells resistant to IFNs.
Takeaway
Filoviruses like Ebola and Marburg can trick our body's defenses, making it hard for us to fight them off. They have special proteins that stop our immune system from working properly.
Methodology
The review discusses biochemical, structural, and cell biological data on filoviral proteins and their interactions with host immune responses.
Limitations
The mechanisms of immune modulation by filoviral components are not fully understood.
Digital Object Identifier (DOI)
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