Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungi
2009

Study of SNARE Proteins in Fungi Evolution

Sample size: 123 publication Evidence: moderate

Author Information

Author(s): Kienle Nickias, Kloepper Tobias H, Fasshauer Dirk

Primary Institution: Max-Planck-Institute for Biophysical Chemistry

Hypothesis

How have SNARE proteins evolved in fungi compared to other eukaryotes?

Conclusion

Fungi possess a relatively simple and conserved set of SNARE proteins, with baker's yeast showing some deviations compared to basal fungi.

Supporting Evidence

  • Fungi generally have a simple set of SNARE proteins.
  • Baker's yeast has gained additional SNAREs through evolution.
  • Vam7 is a unique SNARE protein found only in fungi.

Takeaway

This study looks at special proteins that help cells move things around. It found that fungi have fewer types of these proteins than animals, but yeast has some unique ones.

Methodology

The study analyzed genomic data and classified SNARE proteins from various fungi, constructing phylogenetic trees to understand their evolution.

Limitations

The study does not provide a universal classification scheme for SNARE proteins across all fungi.

Digital Object Identifier (DOI)

10.1186/1471-2148-9-19

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