CCL2/MCP1 Genotype-Phenotype Relationship in Latent Tuberculosis Infection
Author Information
Author(s): Hussain Rabia, Ansari Ambreen, Talat Najeeha, Hasan Zahra, Dawood Ghaffar
Primary Institution: Aga Khan University, Karachi, Pakistan
Hypothesis
The study investigates the relationship between CCL-2 genotype SNP -2518 and plasma CCL-2 levels in relation to tuberculin skin test positivity in asymptomatic individuals.
Conclusion
The study found that higher plasma CCL-2 levels are associated with latent tuberculosis, particularly in individuals with the G allele of the CCL-2 -2518 SNP.
Supporting Evidence
- Plasma CCL-2 levels were significantly higher in TST positive individuals.
- The G allele of CCL-2 -2518 SNP was overrepresented in household contacts compared to community controls.
- Recent exposure to tuberculosis was linked to higher CCL-2 levels.
- Statistical analysis showed significant differences in CCL-2 levels based on TST status.
Takeaway
This study shows that a specific gene variant can affect the levels of a protein related to tuberculosis, which might help us understand who is more likely to get sick.
Methodology
The study analyzed plasma CCL-2 levels and CCL-2 genotype SNP -2518 in asymptomatic controls and household contacts of tuberculosis patients, using statistical tests to assess differences.
Potential Biases
Potential bias due to the selection of control groups and the influence of environmental factors on immune responses.
Limitations
The study may not account for all variables affecting CCL-2 levels, and the sample is limited to a specific population.
Participant Demographics
Participants included BCG vaccinated, asymptomatic healthy controls and household contacts of tuberculosis patients, with no known exposure to tuberculosis.
Statistical Information
P-Value
p=0.004
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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