First Direct Synthesis of β-Unsubstituted Meso-Decamethylcalix[5]pyrrole
Author Information
Author(s): Chacón-García Luis, Chávez Lizbeth, Cacho Denisse R, Altamirano-Hernández Josue
Primary Institution: Laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas
Hypothesis
The study investigates the direct synthesis of β-unsubstituted meso-decamethylcalix[5]pyrrole using bismuth salts.
Conclusion
The synthesis of β-unsubstituted meso-decamethylcalix[5]pyrrole was successfully achieved with moderate yield using Bi(NO3)3.
Supporting Evidence
- Bismuth salts were necessary to obtain calix[5]pyrrole.
- The best results were obtained using Bi(NO3)3.
- The synthesis proceeds without any intermediates.
Takeaway
Scientists found a way to make a special chemical compound using a safe ingredient called bismuth, which helps in the process.
Methodology
The reaction involved mixing Bi(NO3)3, acetone, and pyrrole at room temperature for 6 hours, followed by purification using HPLC.
Limitations
The compound was found to be unstable, which likely decreased the yield.
Digital Object Identifier (DOI)
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