RUNX3 Methylation and Gastric Cancer
Author Information
Author(s): Fan Xiao-yuan, Hu Xin-lei, Han Tie-mei, Wang Na-na, Zhu Yi-miao, Hu Wen, Ma Zhen-hua, Zhang Chen-jing, Xu Xiang, Ye Zai-yuan, Han Chun-mao, Pan Wen-sheng
Primary Institution: Second Affiliated Hospital, Zhejiang University, School of Medicine
Hypothesis
Is there an association between RUNX3 promoter methylation and gastric cancer?
Conclusion
The study found a strong association between RUNX3 promoter methylation and gastric cancer, supporting its role as a tumor suppressor gene.
Supporting Evidence
- The pooled odds ratio for RUNX3 methylation in cancer tissues compared to normal tissues was 5.63.
- Younger individuals had higher RUNX3 methylation rates than older individuals.
- RUNX3 methylation was more frequent in intestinal-type gastric carcinomas compared to diffuse-type.
Takeaway
This study shows that a specific change in a gene called RUNX3 is linked to stomach cancer, which means it might help us understand how this cancer develops.
Methodology
The study systematically reviewed and analyzed data from 17 studies on RUNX3 promoter methylation in gastric cancer using meta-analysis methods.
Potential Biases
There was a risk of bias due to smaller studies reporting more positive associations.
Limitations
The study faced heterogeneity among included studies and potential publication bias.
Participant Demographics
The analysis included 974 participants from various studies, with a mix of ethnic backgrounds.
Statistical Information
P-Value
<0.0001
Confidence Interval
95%CI 3.15, 10.07
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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