Mesenchymal Stem Cells Help Lungs After Hemorrhagic Shock
Author Information
Author(s): Pati Shibani, Gerber Michael H., Menge Tyler D., Wataha Kathryn A., Zhao Yuhai, Baumgartner John Adam, Zhao Jing, Letourneau Phillip A., Huby Maria P., Baer Lisa A., Salsbury John R., Kozar Rosemary A., Wade Charles E., Walker Peter A., Dash Pramod K., Cox Charles S. Jr., Doursout Marie-Francoise, Holcomb John B.
Primary Institution: University of Texas Health Science Center at Houston
Hypothesis
MSCs would have stabilizing effects in the lungs exposed to hemorrhagic shock.
Conclusion
MSCs can inhibit inflammation and preserve lung endothelial integrity after hemorrhagic shock.
Supporting Evidence
- MSCs inhibit systemic levels of inflammatory cytokines in treated animals.
- MSCs preserve vascular endothelial barrier proteins in the lungs.
- MSCs decrease leukocyte infiltrates in the lungs after treatment.
Takeaway
This study shows that special cells called MSCs can help heal the lungs after a serious injury by stopping swelling and inflammation.
Methodology
The study involved in vitro experiments with pulmonary endothelial cells and in vivo tests in a rat model of hemorrhagic shock.
Limitations
The study was conducted in a rat model, which may not fully replicate human responses.
Participant Demographics
Male Sprague-Dawley rats were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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