The Role of SPHK1 in Esophageal Cancer Metastasis
Author Information
Author(s): Pan Jian, Tao Yan-Fang, Zhou Zhuan, Cao Bang-rong, Wu Shui-Yan, Zhang Yan-Lan, Hu Shao-Yan, Zhao Wen-Li, Wang Jian, Lou Guo-Liang, Li Zhen, Feng Xing, Ni Jian
Primary Institution: Children's Hospital of Soochow University, Suzhou, China
Hypothesis
The study investigates the role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma.
Conclusion
SPHK1 is implicated in the metastasis of esophageal cancer and may serve as a therapeutic target.
Supporting Evidence
- SPHK1 was overexpressed in the highly invasive EC9706-P4 subline.
- SPHK1 expression correlated with the depth of tumor invasion and lymph node metastasis.
- Strong SPHK1 expression was significantly associated with clinical failure.
Takeaway
SPHK1 is a protein that helps esophageal cancer cells spread, and targeting it might help treat the disease.
Methodology
The study used a Matrigel invasion model and analyzed gene expression through microarrays, RT-PCR, and Western blotting.
Participant Demographics
Patients with esophageal squamous cell carcinoma from the Chinese Academy of Medical Sciences Cancer Hospital.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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