HIV-1 and Cellular Kinases: Active or Passive Participants?
Author Information
Author(s): Giroud Charline, Chazal Nathalie, Briant Laurence
Primary Institution: Centre d'études d'agents Pathogènes et Biotechnologies pour la Santé (CPBS), UMR5236 CNRS - Université Montpellier 1-Montpellier 2, Montpellier, France
Hypothesis
Do cellular kinases play an active role in the HIV-1 life cycle or are they merely passively incorporated into the virus?
Conclusion
Cellular kinases packaged into HIV-1 particles are essential for viral infectivity and play significant roles in various steps of the viral life cycle.
Supporting Evidence
- Cellular kinases are incorporated into HIV-1 particles during the budding process.
- ERK2 and PKA are examples of kinases that play roles in HIV-1 infectivity.
- Phosphorylation of viral proteins by these kinases is crucial for the viral life cycle.
- Different host cell types can influence the profile of kinases packaged into HIV-1.
Takeaway
HIV-1 takes some proteins from human cells, called kinases, which help the virus to grow and spread. These kinases are important for the virus to work properly.
Methodology
The review summarizes findings from various studies on the presence and role of cellular kinases in HIV-1 particles, including biochemical assays and mass spectrometry.
Limitations
The review does not provide experimental data but summarizes existing literature, which may not cover all aspects of kinase functionality.
Digital Object Identifier (DOI)
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