Evolution of Histone Variants H2A.Z-1 and H2A.Z-2 in Chordates
Author Information
Author(s): Eirín-López José M, González-Romero Rodrigo, Dryhurst Deanna, Ishibashi Toyotaka, Ausió Juan
Primary Institution: Universidade da Coruña
Hypothesis
The evolutionary differentiation of two histone H2A.Z variants in chordates is mediated by a stepwise mutation process.
Conclusion
H2A.Z-2 is more evolutionarily constrained than H2A.Z-1, suggesting functional diversification between the two variants.
Supporting Evidence
- H2A.Z-1 and H2A.Z-2 share a common evolutionary origin early in chordate evolution.
- The differentiation between H2A.Z-1 and H2A.Z-2 involves refined stepwise mutation changes.
- H2A.Z-2 is subject to strong purifying selection.
Takeaway
There are two types of histones called H2A.Z-1 and H2A.Z-2 that help organize DNA in cells, and they have evolved differently over time.
Methodology
The study involved extensive DNA and protein database mining, phylogenetic analysis, and examination of amino acid and nucleotide variation.
Limitations
The functional significance of H2A.Z-2 remains unclear and requires further research.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website