Chios Mastic Gum Reduces Inflammation by Inhibiting Oxidative Stress
Author Information
Author(s): Triantafyllou Angelike, Bikineyeva Alfiya, Dikalova Anna, Nazarewicz Rafal, Lerakis Stamatios, Dikalov Sergey
Primary Institution: Emory University School of Medicine
Hypothesis
The anti-inflammatory activity of Chios mastic gum is associated with its potential antioxidant activity.
Conclusion
Mastic gum inhibits the production of superoxide and hydrogen peroxide by blocking the activation of NADPH oxidases through PKC inhibition.
Supporting Evidence
- Mastic gum inhibited cellular production of superoxide and hydrogen peroxide in a dose-dependent manner.
- TNF-α significantly increased cellular superoxide production, which mastic gum completely abolished.
- Mastic gum inhibited the activity of purified PKC, decreasing PKC activity in cell homogenate.
Takeaway
Chios mastic gum can help reduce inflammation by stopping the body from making harmful substances that cause stress and damage.
Methodology
The study used electron spin resonance and high-performance liquid chromatography to measure superoxide and hydrogen peroxide production in cells treated with mastic gum.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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