Using Intra-Rectal Quinine for Malaria Treatment in Mali
Author Information
Author(s): Thera Mahamadou A, Keita Falaye, Sissoko Mahamadou S, Traoré Oumar B, Coulibaly Drissa, Sacko Massambou, Lameyre Valerie, Ducret Jean Pascal, Doumbo Ogobara
Primary Institution: Malaria Research and Training Centre, University of Bamako, Mali
Hypothesis
Can intra-rectal quinine alkaloids effectively treat non-per os malaria in children at peripheral health care facilities?
Conclusion
Intra-rectal quinine alkaloids were well accepted and effective for treating severe malaria in children at peripheral health care facilities in Mopti, Mali.
Supporting Evidence
- 67% of children and 92% of parents accepted the intra-rectal route.
- 84% of health care workers found the kit easy to use.
- The case fatality rate for severe malaria was 7.2%.
Takeaway
Doctors in Mali found that giving medicine through the bottom worked well for kids with malaria, and both kids and their parents liked it.
Methodology
A single-arm trial was conducted where children received intra-rectal quinine and were then referred to hospitals for further treatment.
Potential Biases
Potential bias in including children with severe conditions that may not represent typical cases of non-per os malaria.
Limitations
The study may have included children with less survival chances, affecting the generalizability of the results.
Participant Demographics
Median age of participants was 33 months, with 53.7% being male.
Statistical Information
P-Value
0.023
Confidence Interval
95% CI [3.85–13.89]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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