Suppressive Effect of Juzen-Taiho-To on Lung Metastasis of B16 Melanoma Cells In Vivo
2011
Juzen-Taiho-To's Effect on Melanoma Spread in Mice
Sample size: 10
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Matsuda Takako, Maekawa Katsuhiko, Asano Kazuhito, Hisamitsu Tadashi
Primary Institution: Showa University
Hypothesis
Can Juzen-Taiho-To prevent cancer metastasis in mice?
Conclusion
Juzen-Taiho-To significantly inhibits the metastasis of B16 melanoma cells in the lungs of mice.
Supporting Evidence
- Oral administration of JTT at 0.2% and 1.0% significantly inhibited tumor metastasis in lungs.
- JTT at 1.0% also suppressed spontaneous metastasis from hind footpad to lung.
- Injection of anti-NK1.1 mAb eliminated JTT's ability to prevent tumor cell metastasis.
Takeaway
Juzen-Taiho-To, a Japanese herbal medicine, helps stop cancer cells from spreading in mice.
Methodology
C57BL/6 male mice were fed diets containing Juzen-Taiho-To and injected with B16 melanoma cells to assess tumor metastasis.
Limitations
The specific components of Juzen-Taiho-To responsible for its effects are not identified.
Participant Demographics
C57BL/6 male mice, 6 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website