Cyclin D1 and Colorectal Cancer: A Study on Gender Differences
Author Information
Author(s): Wangefjord Sakarias, Manjer Jonas, Gaber Alexander, Nodin Björn, Eberhard Jakob, Jirström Karin
Primary Institution: Lund University
Hypothesis
Cyclin D1 expression and its prognostic effects differ according to gender in colorectal cancer.
Conclusion
Cyclin D1 expression is associated with prolonged survival in male colorectal cancer patients but not in female patients.
Supporting Evidence
- Cyclin D1 intensity was significantly lower in male compared to female colorectal cancer.
- In men, cyclin D1 expression was associated with a significantly prolonged cancer-specific survival.
- In women, cyclin D1 was not prognostic for cancer-specific survival.
Takeaway
This study found that a protein called cyclin D1 helps men with colon cancer live longer, but it doesn't have the same effect for women.
Methodology
The study used tissue microarrays and immunohistochemistry to evaluate cyclin D1 expression in 527 colorectal cancer cases.
Potential Biases
Potential selection bias due to the population-based nature of the study.
Limitations
The prognostic value of cyclin D1 was not retained in multivariate analysis.
Participant Demographics
The cohort included 39.4% men and 60.6% women, aged 44 to 74 years.
Statistical Information
P-Value
0.026
Confidence Interval
95% CI 0.49 to 0.96
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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