Cyclin D1 expression in colorectal cancer is a favorable prognostic factor in men but not in women in a prospective, population-based cohort study
2011

Cyclin D1 and Colorectal Cancer: A Study on Gender Differences

Sample size: 527 publication Evidence: moderate

Author Information

Author(s): Wangefjord Sakarias, Manjer Jonas, Gaber Alexander, Nodin Björn, Eberhard Jakob, Jirström Karin

Primary Institution: Lund University

Hypothesis

Cyclin D1 expression and its prognostic effects differ according to gender in colorectal cancer.

Conclusion

Cyclin D1 expression is associated with prolonged survival in male colorectal cancer patients but not in female patients.

Supporting Evidence

  • Cyclin D1 intensity was significantly lower in male compared to female colorectal cancer.
  • In men, cyclin D1 expression was associated with a significantly prolonged cancer-specific survival.
  • In women, cyclin D1 was not prognostic for cancer-specific survival.

Takeaway

This study found that a protein called cyclin D1 helps men with colon cancer live longer, but it doesn't have the same effect for women.

Methodology

The study used tissue microarrays and immunohistochemistry to evaluate cyclin D1 expression in 527 colorectal cancer cases.

Potential Biases

Potential selection bias due to the population-based nature of the study.

Limitations

The prognostic value of cyclin D1 was not retained in multivariate analysis.

Participant Demographics

The cohort included 39.4% men and 60.6% women, aged 44 to 74 years.

Statistical Information

P-Value

0.026

Confidence Interval

95% CI 0.49 to 0.96

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1186/2042-6410-2-10

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