Amyloid Deposits in Transplanted Human Pancreatic Islets
Author Information
Author(s): Andersson Arne, Bohman Sara, Borg L. A. Håkan, Paulsson Johan F., Schultz Sebastian W., Westermark Gunilla T., Westermark Per
Primary Institution: Uppsala University and Linköping University
Hypothesis
Amyloid formation may be a potential cause of long-term failure in transplanted human pancreatic islets.
Conclusion
The study suggests that amyloid deposits form rapidly in transplanted human islets and may contribute to their long-term failure.
Supporting Evidence
- Amyloid deposits were found in human islet transplants in six out of eight normoglycaemic and two out of four hyperglycaemic recipients.
- The study demonstrated that amyloid formation occurs rapidly after transplantation.
- Long-term hyperglycemia was shown to influence the dynamics of amyloid formation in islets.
Takeaway
When doctors put new insulin-producing cells into people with diabetes, some of these cells can get sick and form a sticky substance called amyloid, which can make them stop working over time.
Methodology
The study reviews laboratory attempts to understand the dynamics and mechanisms of amyloid formation in transplanted islets, particularly under long-term hyperglycemic conditions.
Limitations
The study primarily focuses on animal models, which may not fully replicate human conditions.
Participant Demographics
The study involved 36 subjects with type 1 diabetes who underwent islet transplantation.
Digital Object Identifier (DOI)
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