Cranberry and Grape Seed Extracts Inhibit Oral Cancer Cell Growth
Author Information
Author(s): Kourt Chatelain, Spencer Phippen, Jonathan McCabe, Christopher A. Teeters, Susan O'Malley, Karl Kingsley
Primary Institution: University of Nevada, Las Vegas
Hypothesis
Both cranberry and grape seed extracts can inhibit the proliferation of oral squamous cell carcinoma.
Conclusion
Cranberry and grape seed extracts significantly inhibit the growth of oral cancer cells in a dose-dependent manner.
Supporting Evidence
- Cranberry and grape seed extracts inhibited the proliferation of CAL27 and SCC25 oral cancer cell lines.
- The inhibition of cell growth was dose-dependent for both extracts.
- Caspase-2 and caspase-8, key regulators of apoptosis, were up-regulated by the treatments.
- Previous studies indicated that proanthocyanidins from grape seed extract had more prominent growth inhibition effects.
Takeaway
Eating cranberries and grapes might help stop certain types of mouth cancer from growing.
Methodology
The study used two oral cancer cell lines and performed proliferation assays with varying concentrations of cranberry and grape seed extracts.
Limitations
The study was conducted in vitro, and results may not directly translate to in vivo conditions.
Statistical Information
P-Value
<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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