Serum Factors and Mitochondrial Aging
Author Information
Author(s): Heimler Stephanie, Chen Brian, Tanaka Toshiko, Moore Ann Zenobia, Bergstrom Jaclyn, Ferrucci Luigi, Molina Anthony
Primary Institution: University of California San Diego
Hypothesis
Can circulating factors in human blood drive age-related bioenergetic decline?
Conclusion
The study suggests that circulating factors in blood may explain differences in biological aging among individuals of the same chronological age.
Supporting Evidence
- The study involved serum samples from 88 healthy participants.
- Bioenergetic capacity negatively correlates with the chronological age of the serum donor.
- The effects of serum on fibroblasts were most closely related to second generation epigenetic clocks.
Takeaway
Scientists found that blood from older people can affect how cells use energy, showing that aging can be different for everyone.
Methodology
Fibroblasts from younger and older donors were treated with serum samples from healthy participants to assess bioenergetic capacity.
Participant Demographics
Healthy participants aged 22-92 years, free from major chronic conditions.
Statistical Information
P-Value
P=0.01; P=0.02; P<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website