Recent Advances in Hepatitis C Virus Cell Entry
2010
Recent Advances in Hepatitis C Virus Cell Entry
publication
Evidence: moderate
Author Information
Author(s): Bartosch Birke, Dubuisson Jean
Primary Institution: INSERM, U871, Lyon, France
Conclusion
The association of HCV with lipoproteins enhances its infectivity and helps the virus evade immune detection.
Supporting Evidence
- HCV is associated with lipoproteins, which increases its infectivity.
- Chronic hepatitis C is a leading cause of liver disease worldwide.
- HCV entry requires specific cellular co-factors like CD81 and SR-BI.
Takeaway
Hepatitis C virus (HCV) can attach to and enter liver cells with the help of certain proteins and lipoproteins, which makes it more infectious.
Methodology
This review discusses the molecular mechanisms of HCV cell entry and the roles of various cellular co-factors.
Limitations
The biochemical isolation and characterization of lipoprotein-associated virus is challenging, and the production efficiency of HCV varies with cell culture conditions.
Digital Object Identifier (DOI)
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