Ethanol Extract from Ampelopsis sinica Root and Its Anti-HBV Activity
Author Information
Author(s): Pang Ran, Tao Jun-Yan, Zhang Shu-Ling, Chen Ke-Li, Zhao Lei, Yue Xin, Wang Yue-Feng, Ye Pian, Zhu Ying, Wu Jian-Guo
Primary Institution: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Hypothesis
The study investigates the anti-HBV activity and mechanisms of the ethanol extract from Ampelopsis sinica root (EASR) in vitro.
Conclusion
EASR exerts anti-HBV effects by inhibiting HBV transcription and the p53-associated signaling pathway.
Supporting Evidence
- EASR effectively suppressed the secretion of HBsAg and HBeAg from HepG2 2.2.15 cells in a dose-dependent manner.
- EASR treatment resulted in a significant increase in the percentage of apoptotic cells.
- EASR selectively inhibited the activities of HBV promoters and the p53 signaling pathway.
Takeaway
This study found that a plant extract can help fight a virus that causes liver problems by stopping the virus from making copies of itself.
Methodology
The study used HepG2 2.2.15 cells to test the effects of EASR on HBV markers and signaling pathways through various assays.
Limitations
The study was conducted in vitro, and further in vivo studies are needed to confirm the findings.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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