Longitudinal Study of a Nanoparticulate Contrast Agent in Mice
Author Information
Author(s): Hanne Boll, Stefanie Nittka, Fabian Doyon, Michael Neumaier, Alexander Marx, Martin Kramer, Christoph Groden, Marc A. Brockmann
Primary Institution: Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Hypothesis
Can a nanoparticulate contrast agent provide long-lasting imaging of liver disease in mice?
Conclusion
The nanoparticulate contrast agents ExiTron nano 6000 and 12000 provide strong and prolonged contrast for imaging the liver and other organs in small animals.
Supporting Evidence
- The contrast of liver and spleen peaked after 4–8 hours and lasted for several months.
- ExiTron nano facilitated detection of liver metastases.
- The study demonstrated the feasibility of longitudinal monitoring of liver lesions.
Takeaway
This study shows that a special type of contrast agent can help doctors see liver problems in mice for a long time after just one injection.
Methodology
Mice were injected with two formulations of a nanoparticulate contrast agent and underwent repeated micro-CT imaging over six months.
Limitations
The study was conducted only in mice, which may limit the applicability of the findings to other species.
Participant Demographics
C57BL/6J mice were used in the study.
Digital Object Identifier (DOI)
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