TRANSLATIONAL BIOMARKERS FOR AGING AND FRAILTY: IMPORTANT SEX DIFFERENCES
2024
Sex Differences in Frailty and Health Outcomes in Mice
publication
Author Information
Author(s): Kane Alice
Primary Institution: Institute for Systems Biology, Seattle, Washington, United States
Hypothesis
There are significant sex differences in frailty and its associated biomarkers in mice.
Conclusion
The study found clear sex differences in frailty scores and associated molecular outcomes in mice.
Supporting Evidence
- Female mice have higher frailty scores than males in middle-to-late life.
- Sex explains more variability than age or frailty in DNA methylation data.
- Preliminary analysis identifies hundreds of sex-specific differentially methylated regions with frailty.
- Metabolomics analysis identifies 104 metabolites associated with frailty, independent of sex and age.
- Sex-specific metabolomic markers for frailty include creatine for females and FAD for males.
- Microbiome data identifies microbes associated with frailty across sexes.
Takeaway
This study shows that female mice are generally more frail than male mice, and they have different biological markers related to frailty.
Methodology
The study assessed health outcomes in male and female C57BL/6 mice, collecting blood and stool samples for various analyses.
Participant Demographics
C57BL/6 mice, both male and female.
Digital Object Identifier (DOI)
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