Cell-Free DNA and Frailty in Older Adults
Author Information
Author(s): Nidadavolu Lolita, Sosnowski David, Sivakumar Nikita, Bennett David, Phillip Jude, Maher Brion, Oh Esther, Abadir Peter
Primary Institution: Johns Hopkins University
Hypothesis
Which tissues release cf-gDNA fragments in community-dwelling older adults with frailty?
Conclusion
The study identifies a sub-group of older adults with higher frailty and cardiovascular disease risk based on cf-gDNA tissue origin.
Supporting Evidence
- Cell-free genomic DNA fragments are released into the bloodstream following cell death processes.
- Higher levels of cf-gDNA are associated with age-related physical and cognitive decline.
- Individuals in the Cardiovascular sub-group had higher frailty scores and increased prevalence of cardiovascular diseases.
Takeaway
Scientists found that older people with more cell-free DNA from their heart are more likely to be frail and have heart problems.
Methodology
DNA methylation was performed on cf-gDNA from participants, and associations were examined using linear regression and mixed-effects models.
Participant Demographics
Community-dwelling older adults from the Religious Orders Study and Rush Memory and Aging Project.
Digital Object Identifier (DOI)
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