Sodium Disturbances in ICU Patients
Author Information
Author(s): Stelfox Henry Thomas, Ahmed Sofia B, Khandwala Farah, Zygun David, Shahpori Reza, Laupland Kevin
Primary Institution: University of Calgary
Hypothesis
What is the incidence of ICU-acquired hyponatraemia and hypernatraemia and their effects on outcomes in the ICU?
Conclusion
ICU-acquired hyponatraemia and hypernatraemia are common in critically ill patients and are associated with increased risk of hospital mortality.
Supporting Evidence
- 11% of patients developed ICU-acquired hyponatraemia.
- 26% of patients developed ICU-acquired hypernatraemia.
- Hospital mortality was 28% for hyponatraemia and 34% for hypernatraemia.
Takeaway
Many patients in the ICU can develop problems with their sodium levels, which can make them sicker and increase their chances of dying.
Methodology
The study analyzed data from 8142 adults admitted to three medical-surgical ICUs over seven years, focusing on those with normal sodium levels on the first day of admission.
Potential Biases
The study's observational nature limits causal inferences.
Limitations
The study was observational and did not capture detailed information on interventions like fluid management and medications.
Participant Demographics
The median age was 59.7 years, with 41% female participants.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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