BMAL1 Gene Deficiency Causes Metabolic Issues in Mice
Author Information
Author(s): Shimba Shigeki, Ogawa Tomohiro, Hitosugi Shunsuke, Ichihashi Yuya, Nakadaira Yuki, Kobayashi Munehiro, Tezuka Masakatsu, Kosuge Yasuhiro, Ishige Kumiko, Ito Yoshihisa, Komiyama Kazuo, Okamatsu-Ogura Yuko, Kimura Kazuhiro, Saito Masayuki
Primary Institution: Nihon University, Funabashi, Chiba, Japan
Hypothesis
Does the loss of BMAL1 function induce metabolic syndrome?
Conclusion
Loss of BMAL1 function leads to dyslipidemia and ectopic fat formation, contributing to metabolic syndrome.
Supporting Evidence
- Bmal1-deficient mice showed increased levels of circulating fatty acids.
- Ectopic fat accumulation was observed in the liver and skeletal muscle of Bmal1 -/- mice.
- The study found that BMAL1 is crucial for energy homeostasis.
Takeaway
Mice without the BMAL1 gene have trouble using fat for energy, which makes them gain fat in the wrong places and can lead to health problems.
Methodology
The study involved generating Bmal1-deficient mice and analyzing their metabolic responses to high-fat diets.
Participant Demographics
Mice were used as the model organism.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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