Reduced Expression of Transcription Factor AP-2α Is Associated with Gastric Adenocarcinoma Prognosis
Author Information
Author(s): Wang Wei, Lv Lin, Pan Ke, Zhang Yu, Zhao Jing-jing, Chen Ju-gao, Chen Yi-bing, Li Yong-qiang, Wang Qi-jin, He Jia, Chen Shi-ping, Zhou Zhi-wei, Xia Jian-chuan
Primary Institution: Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China
Hypothesis
This study aims to investigate the expression and prognostic significance of activator protein 2α (AP-2α) in gastric adenocarcinoma.
Conclusion
Reduced AP-2α expression independently predicts an unfavorable prognosis in gastric adenocarcinoma patients.
Supporting Evidence
- AP-2α mRNA was reduced in tumor tissue samples compared to adjacent non-tumor tissue samples.
- Reduced AP-2α expression was significantly associated with poorly differentiated tumors.
- Patients with low AP-2α expression had a significantly shorter overall survival than those with high expressions.
- Multivariate analysis identified AP-2α expression as an independent prognostic factor for overall survival.
Takeaway
This study found that lower levels of a protein called AP-2α in stomach cancer patients mean they are more likely to have a worse outcome.
Methodology
AP-2α expression was analyzed using real-time quantitative PCR, western blotting, and immunohistochemical staining methods on tissue samples from gastric adenocarcinoma patients.
Participant Demographics
The study included 481 gastric cancer patients, with a median age of 58 years, comprising 326 males and 155 females.
Statistical Information
P-Value
P<0.001
Confidence Interval
95% CI 1.127–2.029
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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