Heart's Release of Chemo-attractant Cytokines After Heart Attack
Author Information
Author(s): Andrew J Boyle, Yerem Yeghiazarians, Henry Shih, Joy Hwang, Jianqin Ye, Rich Sievers, Daiwei Zheng, Jath Palasubramaniam, Dharshan Palasubramaniam, Connie Karschimkus, Robert Whitbourn, Alicia Jenkins, Andrew M Wilson
Primary Institution: University of California San Francisco
Hypothesis
It remains unknown if MCP-1 and SDF-1a are produced by and released from the heart to attract stem cells for repair after myocardial infarction.
Conclusion
SDF-1a and MCP-1 release from the human heart are suppressed following myocardial infarction, contrasting with the animal model for MCP-1.
Supporting Evidence
- SDF-1a release is suppressed in all stages of coronary artery disease.
- MCP-1 release from the heart is suppressed following myocardial infarction.
- The changes in cardiac production and release of SDF-1a in response to MI appear to be similar in the mouse and human.
- Human observational studies are important to confirm whether the human disease state is accurately reflected by the animal model.
Takeaway
After a heart attack, the heart doesn't release certain chemicals that help repair it, which is different in mice and humans.
Methodology
The study involved murine hearts and human blood samples to analyze the expression and release of MCP-1 and SDF-1a after myocardial infarction.
Potential Biases
There were more males in the coronary artery disease groups than in the normal control group, which may influence results.
Limitations
The study did not directly compare human mRNA to murine mRNA due to difficulties in procuring human heart tissue.
Participant Demographics
The study included 21 patients with myocardial infarction, with a higher percentage of males (90%) compared to controls.
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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