Horizontal Transmission of Candida albicans and Vaccine Response in Mice
Author Information
Author(s): Jim E. Cutler, Miriam Corti, Patrick Lambert, Michael Ferris, Hong Xin
Primary Institution: Louisiana State University Health Sciences Center
Hypothesis
How does Candida albicans colonization and serum antibodies affect vaccine responses in mice?
Conclusion
Mice colonized with Candida albicans can still produce antibodies in response to a vaccine despite the presence of the fungus.
Supporting Evidence
- Candida colonization occurred in mice treated with antibiotics.
- Many Candida-colonized mice developed serum fungal-specific antibodies.
- Colonized mice were still able to produce antibodies in response to the Fba immunogen.
Takeaway
The study shows that mice can get a fungus called Candida from other mice and still respond to a vaccine against it.
Methodology
Mice were colonized with Candida albicans and then vaccinated with a peptide vaccine to assess immune response.
Potential Biases
Potential for cross-contamination during handling of mice.
Limitations
The study's findings may not fully translate to humans due to differences in immune responses between species.
Participant Demographics
C57BL/6 and BALB/c female mice, 2–3 months old.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website