The Hoover's Sign of Pulmonary Disease: Molecular Basis and Clinical Relevance
2008

Understanding Hoover's Sign in Pulmonary Disease

publication Evidence: moderate

Author Information

Author(s): Johnston Chambless R III, Krishnaswamy Narayanaswamy, Krishnaswamy Guha

Primary Institution: Quillen College of Medicine and James H. Quillen VA Medical Center

Hypothesis

Hoover's sign can serve as a valuable clinical marker for severe airway obstruction.

Conclusion

Hoover's sign is associated with severe airway obstruction and can provide important prognostic information.

Supporting Evidence

  • Hoover's sign has a sensitivity of 58% and specificity of 86% for detecting airway obstruction.
  • Up to 70% of patients with severe obstruction exhibit Hoover's sign.
  • The sign is associated with body mass index, severity of dyspnea, and frequency of exacerbations.

Takeaway

Hoover's sign is a physical sign that shows when someone has serious breathing problems, and doctors can use it to help treat patients quickly.

Methodology

The study reviews clinical and molecular aspects of Hoover's sign and its implications in airway disease management.

Limitations

There is limited data on the cost-effectiveness of using Hoover's sign compared to other diagnostic methods.

Participant Demographics

The study includes patients with chronic obstructive pulmonary disease (COPD), asthma, and other respiratory conditions.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1476-7961-6-8

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