Anti-Cancer Effects of Protein Extracts from Three Mushrooms
Author Information
Author(s): Wu Jin-Yi, Chen Chi-Hung, Chang Wen-Huei, Chung King-Thom, Liu Yi-Wen, Lu Fung-Jou, Chen Ching-Hsein
Primary Institution: National Chiayi University
Hypothesis
The study aims to evaluate the anti-cancer effects of protein extracts from Calvatia lilacina, Pleurotus ostreatus, and Volvariella volvacea on human colorectal cancer and monocytic leukemia cells.
Conclusion
The protein extracts of these mushrooms exhibited therapeutic efficacy against human colorectal adenocarcinoma and monocytic leukemia cells.
Supporting Evidence
- The protein extracts of PO and VV induced significant apoptosis in SW480 cells.
- Treatment with PO and VV protein extracts resulted in increased reactive oxygen species production.
- Both extracts caused glutathione depletion and loss of mitochondrial membrane potential in cancer cells.
Takeaway
This study found that certain mushrooms can help kill cancer cells, which might lead to new cancer treatments.
Methodology
Cell viability was evaluated using the MTT assay, and apoptosis was analyzed through flow cytometry after treatment with protein extracts.
Limitations
The exact mechanisms of apoptosis induced by the protein extracts of VV remain unclear.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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