The Mouse Limb Anatomy Atlas: A 3D Tool for Studying Limb Development
Author Information
Author(s): DeLaurier A, Burton N, Bennett M, Baldock R, Davidson D, Mohun T J, Logan M
Primary Institution: National Institute for Medical Research
Hypothesis
Can a 3D interactive atlas improve the study of embryonic limb anatomy in mice?
Conclusion
The Mouse Limb Anatomy Atlas is a valuable resource for researchers studying limb development and congenital abnormalities.
Supporting Evidence
- The atlas features over 60 individually segmented structures of the mouse limb.
- It provides a standardised naming system for limb structures.
- The resource is free and accessible to researchers and educators.
Takeaway
This study created a free online tool that helps scientists see and understand the muscles and bones in developing mouse limbs in 3D, making it easier to study limb growth and problems.
Methodology
The atlas was created using Optical Projection Tomography (OPT) to scan and reconstruct 3D models of mouse limbs at embryonic day 14.5.
Limitations
The study primarily focuses on E14.5 limbs, which may not represent all developmental stages.
Digital Object Identifier (DOI)
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