Predicting Lymph Node Metastasis in Prostate Cancer Surgery
Author Information
Author(s): Otto Wolfgang, Gerber Peter, Rößler Wolfgang, Wieland Wolf F., Denzinger Stefan
Primary Institution: Department of Urology, St. Josef Medical Centre, University of Regensburg
Hypothesis
Positive surgical margins can predict lymph node metastasis in patients with locally advanced prostate carcinoma.
Conclusion
Positive surgical margins are a significant predictor of lymph node involvement in locally advanced prostate cancer patients.
Supporting Evidence
- 76% of patients had positive surgical margins.
- 85% of patients with positive margins had lymph node metastasis.
- Neoadjuvant antihormonal treatment reduced positive margins to 60%.
Takeaway
Doctors can tell if prostate cancer has spread to lymph nodes by looking at the edges of the tissue removed during surgery.
Methodology
Retrospective analysis of clinical and histopathological data from 34 patients who underwent radical prostatectomy.
Limitations
The study is based on a small, single-centre patient group.
Participant Demographics
Median age of participants was 65 years, with a range from 55 to 75 years.
Digital Object Identifier (DOI)
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