TNF-α Genetic Variants and Neonatal Bronchopulmonary Dysplasia
Author Information
Author(s): Shams Seyedeh Elham, Dastgheib Seyed Alireza, Mousavi-Beni Seyede Arefe, Hosein Lookzadeh Mohamad, Mirjalili Seyed Reza, Golshan-Tafti Mohammad, Bahrami Reza, Yeganegi Maryam, Shahbazi Amirhossein, Masoudi Ali, Shiri Amirmasoud, Noorishadkam Mahmood, Neamatzadeh Hossein
Hypothesis
This study aims to examine the relationship between TNF-α polymorphisms and the risk of bronchopulmonary dysplasia (BPD).
Conclusion
The study found a significant association between the TNF-α −238G/A polymorphism and the susceptibility to BPD in preterm neonates.
Supporting Evidence
- A total of 14 case-control studies were included in the meta-analysis.
- Significant associations were found for the TNF-α −238G/A polymorphism.
- No significant relationships were observed for the TNF-α −308G/A, −857C/T, and 1,031 T/C polymorphisms.
- Population variability complicates the interpretation of the link between TNF-α polymorphisms and BPD risk.
- Ethnic differences were noted, with significant associations in Asian populations.
Takeaway
This study looked at how certain genes might affect the risk of a lung problem in premature babies, finding one gene that seems to increase that risk.
Methodology
The study conducted a systematic review of 14 case-control studies examining TNF-α polymorphisms and BPD risk.
Potential Biases
Possible publication bias and variability in study populations may affect the reliability of the conclusions.
Limitations
The meta-analysis has limitations, including potential publication bias and heterogeneity due to the small number of studies.
Participant Demographics
The studies included neonates from various ethnic backgrounds, including Asian, Caucasian, and African populations.
Statistical Information
P-Value
p≤0.001 for the significant association with TNF-α −238G/A polymorphism.
Confidence Interval
95% CI 1.527–2.281 for the association with TNF-α −238G/A.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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