TCF7L2 Variants and Type 2 Diabetes Risk in Arabs
Author Information
Author(s): Alsmadi Osama, Al-Rubeaan Khalid, Mohamed Gamal, Alkayal Fadi, Al-Saud Haya, Al-Saud Nouran Abu, Al-Daghri Nasser, Mohammad Shahinaz, Meyer Brian F
Primary Institution: King Faisal Specialist Hospital and Research Center
Hypothesis
Do TCF7L2 variants rs7903146 and rs12255372 contribute to the risk of type 2 diabetes in an Arab population?
Conclusion
The study found weak or no association of TCF7L2 variants with type 2 diabetes in Arabs.
Supporting Evidence
- The T allele frequency for rs7903146 was similar in cases and controls.
- The study was sufficiently powered to detect an effect of similar magnitude to previous meta-analyses.
- Retrospective power calculations indicated a high power to detect associations.
Takeaway
The researchers looked at two gene variants to see if they cause diabetes in Arab people, but they found that they don't seem to be linked.
Methodology
A case-control study with 522 T2D patients and 346 controls, genotyping performed by pyrosequencing.
Limitations
The study cannot rule out the effect of other SNPs in the TCF7L2 gene.
Participant Demographics
Participants were Saudi T2D patients aged 60 and above, with controls being unrelated individuals of similar age.
Statistical Information
P-Value
0.675 for rs7903146; 0.601 for rs12255372
Confidence Interval
95% CI of 0.86–1.27 for rs7903146; 95% CI of 0.86–1.29 for rs12255372
Statistical Significance
p=0.675 for rs7903146; p=0.601 for rs12255372
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website