The Natural Killer Cell Cytotoxic Function Is Modulated by HIV-1 Accessory Proteins
2011
How HIV-1 Affects Natural Killer Cells
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Sowrirajan Bharatwaj, Barker Edward
Primary Institution: Rush University Medical Center
Hypothesis
HIV-1 modulates the function of natural killer (NK) cells through its accessory proteins.
Conclusion
HIV-1 evades destruction by NK cells by down modulating key receptors and ligands necessary for NK cell activation and degranulation.
Supporting Evidence
- HIV-1 Vpr induces expression of ligands for the NK cell activating receptor NKG2D.
- HIV-1 Nef down modulates ligands for the activating receptor NKG2D.
- HIV-1 Vpu down modulates the co-activating receptor NTB-A, preventing NK cell degranulation.
Takeaway
HIV-1 tricks the body's immune cells, called natural killer cells, so they can't effectively kill the infected cells.
Methodology
This review discusses the mechanisms by which HIV-1 proteins affect NK cell function.
Limitations
The review does not provide experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website