Oncogenic Potential of Hepatitis C Virus Proteins
2010
Oncogenic Potential of Hepatitis C Virus Proteins
publication
Evidence: moderate
Author Information
Author(s): Arup Banerjee, Ratna B. Ray, Ranjit Ray
Primary Institution: Edward A. Doisy Research Center
Hypothesis
HCV proteins contribute to hepatocellular carcinoma (HCC) development through various cellular mechanisms.
Conclusion
HCV proteins play significant roles in promoting liver cancer by modulating host cell processes.
Supporting Evidence
- HCV proteins interact with host cell factors to promote cell growth and transformation.
- Chronic HCV infection is a major risk factor for liver disease progression.
- Induction of oxidative stress by HCV proteins may contribute to hepatocyte growth promotion.
- HCV core protein can induce tumor formation in transgenic mouse models.
- Expression of HCV proteins has been linked to alterations in cellular signaling pathways.
Takeaway
Hepatitis C virus can make liver cells grow too much, which can lead to cancer.
Methodology
The review discusses various mechanisms by which HCV proteins interact with host cell factors to promote oncogenesis.
Limitations
Most findings are based on artificial cellular systems and need validation in relevant infection models.
Digital Object Identifier (DOI)
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