Distinguishing Oral Acantholytic Squamous Cell Carcinoma from Angiosarcoma
Author Information
Author(s): Driemel Oliver, Müller-Richter Urs DA, Hakim Samer G, Bauer Richard, Berndt Alexander, Kleinheinz Johannes, Reichert Torsten E, Kosmehl Hartwig
Primary Institution: University of Regensburg
Hypothesis
Can specific markers differentiate oral acantholytic squamous cell carcinoma from intraoral angiosarcoma?
Conclusion
Fli-1 in angiosarcoma and laminin-5 in acantholytic squamous cell carcinoma are distinguishing features.
Supporting Evidence
- Both oral angiosarcoma and ASCC show similar histopathological features.
- The peak incidence of angiosarcoma is in the 7th decade, while ASCC peaks in the 6th decade.
- Cytokeratin-positive cells were found in both lesions, but more in ASCC.
- Loss of E-cadherin and β-catenin was noted in ASCC, indicating poor prognosis.
Takeaway
This study looked at two types of mouth cancers to find out how to tell them apart. They found specific markers that can help doctors make the right diagnosis.
Methodology
The study compared histological features and immunohistochemical staining of five tumors: four acantholytic squamous cell carcinomas and one angiosarcoma.
Limitations
The study is based on a small sample size of five cases.
Participant Demographics
One female and four male patients aged between 50 and 68.
Digital Object Identifier (DOI)
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